منابع مشابه
Prolonged fear incubation leads to generalized avoidance behavior in mice.
Long-lasting presence of avoidance and emotional numbing are reliable behavioral markers for PTSD, but little is known about its psychological and biological underpinnings. We employed our recently established mouse model of PTSD (i) to study the emergence of avoidance behavior in the aftermath of a trauma, (ii) to disentangle the impact of context generalization vs. lack of motivation vs. nove...
متن کاملIncubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala.
UNLABELLED Fear-related psychopathologies such as post-traumatic stress disorder are characterized by impaired extinction of fearful memories. Recent behavioral evidence suggests that the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39), via its receptor, the parathyroid hormone 2 receptor (PTH2R), modulates fear memory. Here we examined the anatomical and cellular localization of...
متن کاملBlockade of CB1 receptors prevents retention of extinction but does not increase low preincubated conditioned fear in the fear incubation procedure.
We recently developed a procedure to study fear incubation, in which rats given 100 tone-shock pairings over 10 days show low fear 2 days after conditioned fear training and high fear after 30 days. Notably, fear 2 days after 10 sessions of fear conditioning is lower than fear seen 2 days after a single session of fear conditioning, suggesting that fear is suppressed. Here, we investigate the p...
متن کامل129S1/SvImJ mice display impaired contextual fear extinction, enhanced fear incubation and deficit extinction consolidation phenotypes: rescue via pharmacological and non-pharmacological treatments
Methods and results The present experiments firstly tested whether deficits in extinguishing emotional responses in S1 extends to contextual extinction. No reduction in emotional responses to the context was observed during an extinction training session which indicates generalised inability of S1 to engage associative fear extinction mechanisms. This was in contrast to mice of another 129 stra...
متن کاملexamining the relationship between fear of negative evaluation and communication strategies by iranian efl learners
the purpose of the present study was to investigate the relationship between fear of negative evaluation (fne) and communication strategies (css) among iranian efl learners. it was aimed to examine the differences in the use of communication strategies between speakers with high or low degree of fear of negative evaluation. the current study was a case study consisting of 10 english learners at...
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ژورنال
عنوان ژورنال: Current Protocols in Neuroscience
سال: 2013
ISSN: 1934-8584,1934-8576
DOI: 10.1002/0471142301.ns0627s64